This is really our first complete human study and the results really have been quite astounding compared to the previously available treatments Alopecia areata is an autoimmune form of hair loss where the body attacks the hair follicles and it begins to fall out.
We enrolled patients with at least thirty percent hair loss and we felt this was a good threshold because we wanted to capture those patients who really were very significantly affected by their hair loss And we found that 9 out of 12 patients had at least 50% regrowth So the genetic studies that we’ve been working on.
In the lab for the past five or so years were really critical in pointing for the first time at a potential pathway to target for alopecia areata So, unexpectedly, the JAK signaling pathway really emerged as a targetable pathway for this disease directly from our genetic studies.
In alopecia areata the hair follicle is quietened by the inflammatory response right around the hair follicle and so the JAK inhibitors block the ability of the cytokines that are released by the inflamed cells from acting on the hair follicle So if you cut that off,.
It enables the hair follicle to waken up and grow This is the first time we can talk about drugs that really show objective ability to treat alopecia areata and lead to regrowth in a large percentage of people But I think it’s very important for people to know that these are not cures and a lot work still needs to be done.
To clarify the safety and the best ways to use these drugs First thing to do really is to go back and repeat this now with a placebo group and a larger group of patients perhaps treat them for a longer time even based on this early result.
Alopecia Areata Why does my hair fall out
This is jamie What?! Who said that? Uhm, nobody. Hmm, Okay. Jamie is a typical kid. Jamie likes playing games.
Jamie likes talking to friends. And so Im like, uhm, no way, and shes all, whatever, and I’m like You did not just say that! Am I right?! And sometimes, Jamie has to do tricky homework Jamie is just like you. But one morning, Jamie noticed something strange.
Hang on a minute! Something seems unusual. Aha! I’ve grown taller! No thats not it. I have two eyes! No Ive always had those.
Then suddenly jamie realised Ah! Ive lost my hair! Jamie searched high and low for the missing hair. Hair. Hair. Hair? Hello police, yes, Id like to report a theft. Well I think someones stolen my hair.
What’s so funny?! No, its not a joke! Stop laughing! The police suggested to go and speak to a . So Jamie did just that. You have Alopecia Areata. Jamie?.
Whaaaa? Alopecia Areata. Oh! No thanks, Im not hungry. No, thats the condition you have. Thats why your hair is gone. Oh! Alotetica Agliata Alopecia Areata.
Aha. agronecia alaberpa. Alopecia Areata. Agaloha Applefalpha Listen to me say it.Alopecia Areata Alopecia Areata Thats it!.
Aha! whats that? Well, Alopecia Areata is a condition where you lose your hair Sometimes people lose all of the hair on their body, but it affects people in different ways. Alopecia is just where your hair follicles fall out, cause yeah, they just dont like you. I have Alopecia Areata Universalis, so total loss of all hair. I first was diagnosed with Alopecia where all of my hair falls out,.