About 800,000 people in Japan are suffering from thinning hair. To provide hope, a new hair loss treatment is emerging. The black hair on the nude mice shown here are not implanted or grafted. They are being regenerated using a regenerative therapy technique. Regenerative therapy is used for hair loss treatment. iPS cells are used as well. These are iPS cells in the middle of differentiation induction. Hair treatment using cutting edge science is emerging.
Thanks to the new regenerative medicine technology, we can regenerate hairs from cells. Hair generation starts in a very small organ present in the dermis. To generate hair, appropriate cells are needed. Cell to cell interaction is important. We need to focus on recreating the natural hair regenerative process as accurately as possible. Today we are showing the science behind hair regeneration: what is happening at a cellular level in the scalp. Science ZERO Japan It’s exciting! Hair treatment using cell therapy. I’d love to try it myself! I think a lot of people are interested in learning about this new therapy.
Do you know how your hairs grow and shed? All I know is that hair grows from hair follicles, but I don’t know much abut the mechanism. To understand the mechanism of hair growth, you need to know what is going on inside hair follicles. The structure you see here is called a hair follicle. The hair follicle functions like a ‘hair regeneration factory’. It can be divided into 2 compartments. The outer part of the hair follicle envelopes a hair fiber. The other part (inner compartment of the hair follicle) is a collection of important cells called dermal papilla cells. Dermal papilla cells instruct hair matrix cells to replicate.
They are instructed to push cells to grow upward, inducing them to differentiate into a hair shaft and elongating hair fiber. Hair is a group of cells which are pushed upward after cell division. That’s right. This is a tutorial clip that shows you how hair grows. Wow, amazing. It looks as if the hair is physically being pushed up. The question we would like to ask here is why we lose hair. Let’s ask scientists about it. (Professor Akio Sato from Kitasato University School of Medicine) It is very important to understand hair cycle when we talk about thinning hair. A hair cycle is a growth cycle of hair.
Hair cycle has three different cycles. The first one is called Anagen phase, which lasts for two to six years. The next phase is called Catagen phase, at which cell division slows down. The last phase is called Telogen phase, which is a resting stage where no cell division occurs. The hair is shed at the end. Are the cycles repeated? Yes, since Anagen phase is the longest of all 3 cycles, hair always appears thick. I understood that hair thinning occurs when the hair cycle is disrupted. But what causes this disruption? Typically, it is thought that thinning is caused by the effects of a male hormone, called androgen. Through an enzymatic reaction, this male hormone is converted into a more active form. This form is believed to have detrimental effects on the hair cycle such an inhibition of cell division.
The cells appear unhealthy here. In this case, a Catagen phase comes early, shortening the hair cycle. And the shortened cycle is repeated. Before hair has a change to be elongated, this short cycle ends, and a new short cycle begins, resulting in thinning hair. For healthy hair regeneration, it needs enough time to grow. When you have a close look at the scalp of thinned hair, you can see a lot of short hairs. You’re right. There are lots of short hairs. It’s not completely bald! Hair follicles in the scalp of the people with thinning hair are not dead. Dermal papilla cells stop sending stimulatory signals, shortening the hair cycle. This is why hair appears thinner.
What’s the scoop on current hair loss treatment? There is a medical product in the market that antagonizes the male hormone. The drawback of this product is that people have to continuously take it to have lasting effects. However, there is a new therapy under development that has potential to stimulate dermal papilla cells to promote hair regeneration. This is Shiseido’s research center in Yokohama, Japan. The hair research team at Shiseido is focusing on development of a cellbased regenerative medicine technology for hair loss. Project leader, Jiro Kishimoto, is a hair research expert, with more than 20 years of experience. We start the process by isolating hair follicles from a scalp sample. These are human scalp samples provided for research purposes after surgical procedures.
New Hair Loss Treatment Could Mean the End of Baldness
(Image source: Columbia University Claire Higgins) BY STEVEN SPARKMAN Scientists might have just taken a big step toward curing baldness. A new technique has been used to grow completely new hair in human skin samples. The research focuses on a type of cell called dermal papilla cells, which have the ability to grow new hair follicles â€” even when injected into skin that doesn’t normally grow hair at all. (Via Columbia University) quot;They took samples from hair follicles from seven volunteers, cloned those cells in the.
Laboratory then implanted them in human skin that was grafted onto the backs of mice. . It resulted in the creation of new hair follicles that grew healthy hair.quot; (Via Fox News) Scientists have known about this technique for decades, and while it works like a charm with mouse cells, for some reason dermal papilla cells from humans just didn’t want to cooperate. Now, researchers have found a simple change to how the human cells are grown makes all the difference. Basically, they flipped the petri dish upside down, allowing the cells to clump together. (Via Columbia University) It’s estimated that Americans spend about $3.5 billion every year trying to overcome.
Hair loss â€” even though, as WebMD puts it. (Via WCBS) quot;The vast majority of hair loss treatments being marketed today are still nothing but ‘snake oils.’quot; Barring a cure, some settle for just looking like they have a full head of hair, with tattooing. quot;Mike’s wife watches as he gets the first of more than 10,000 marks on his scalp.quot; (Via ABC) Or even having hair follicle transplant surgery, which can be costly and leave scars. (Via Wikimedia Commons).
All of this shows just how desperate people are for a cure â€” especially women, who often have a much tougher time when they start losing their hair. quot;.when you wake up every day and wonder what your hair will look like. It affects your confidence, it affects your ability to go out in the world, it affects just about every aspect of your life.quot; (Via The New York Times) That was Angela Christiano, one of the researchers behind the new technique, who has been open about her struggles with alopecia areata, an autoimmune disease that causes hair loss. (Via The New York Times).
Other scientists praised Christiano’s work, calling it a big step forward in the field, but say the technique still needs a lot of refinement before it could help any of the roughly 80 million Americans who are suffering from hair loss.